Endocrine Abstracts

Discussion/Conclusion: Sexual & reproductive health are important areas to be considered in the care of young people with Type 1 diabetes remembering that risk-taking behaviour is more common in those with chronic conditions. Education and advice about sexual health & contraception should be provided taking into account any background cultural and religious differences. Adolescent girls with diabetes should be aware of the importance of a planned pregnancy and that ovu...

Polycystic ovary syndrome (PCOS) may be diagnosed in adult women using the Rotterdam criteria and includes the presence of at least two of the following:- androgen excess, ovulatory dysfunction, or polycystic ovaries on ultrasound scan. The diagnosis of PCOS in adolescents is challenging since these criteria may define normal pubertal physiological features. PCOS is a diagnosis of exclusion and investigation for other possible underlying pathologies, such as non-classical cong...

Girls with ovarian failure or delayed puberty may be treated with incremental doses of oestrogen to induce puberty. Transdermal natural oestradiol is more physiological than oral synthetic ethinyl oestradiol but it is unclear how effective it is for inducing puberty and whether it confers any benefit.The aims of the audit were to review whether transdermal oestradiol was effective in inducing puberty, the optimal dosing regimen, effects on breast develop...

Salt-losing conditions can be challenging to manage well in infancy and early childhood. We describe a child with both salt-wasting 21-hydroxylase deficiency (SW21OHD) and cystic fibrosis (CF).A male infant, JW, birth weight 3.5 kg, presented with a salt-wasting crisis on day 9 of life with hyponatraemia, hyperkalaemia, and weight loss of 415 g. Serum 17-hydroxyprogesterone (17OHP) was >1000 nmol/l and a diagnosis of SW21OHD was made. Neonatal screen...